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It seems for the past few months the latest hot topic is about the substance called methylene blue(MB)… I’ve seen many MD doctors talk about it for many different ailments include SarsCOV2 and for those vaccinated(with damage), even for some people lately with asymmetrical faces… but what is this substance, is it safe and why the rave?
I decided to dig into the research a little bit, as I personally had very limited knowledge of the substance other than it was used in my microbiology labs.
You may have heard of MB used in the past to clean fish tanks.. It was actually one of the first synthetic chemicals used as a medication, but was a textile dye for blue jeans. However, they found it had all kinds of medicinal benefits…
In 1891, German physician and noble prize winner Paul Ehrlich first used methylene blue for the treatment of malaria. His discovery found that MB quickly concentrates in the brain and selectively targets diseased tissues in the body. He found two major properties of MB- it concentrates on nervous tissue, and secondly when injected to the malaria parasite it inhibited a particular enzyme and made it weaker. All synthetic medications were derivatives of MB as a parent compound. It’s also the parent compound of hydroxy-chloroquine, which along with ivermectin are both anti parasitic medications that were effective against SarsCOV2.
Some blood transfusions currently still use MB for its antiviral properties to stop HIV virus… It’s the only compound that is also utilized as the only antidote for metabolic poisons. Any poison that interferes with oxygen transport from blood or from the mitochondria (where oxygen is used for energy) they use MB. Often times its used for carbon monoxide poisoning ( this is where the dropping side of the face or eye symptoms are coming into play, typically the asymmetrical face presentation is CO poisoning OR cranial distortions ;)). It’s important to mention here as well that some infections also induce the expression of heme oxygenase which results in increased carbon monoxide formation inside of the body. You can read here if you like. Which basically means some infection can create CO poisoning inside of you…
Other than using MB acutely, using low dose of MB long term has not been used, and this is where the research has been coming in, to not just use it acutely, but for energy metabolism and for oxygen utilization..Dr Francisco Gonzalez-Lima an expert on Neurodegenerative Diseases has been researching MB and is a prominent researcher at the university of Texas. He’s been discovering through research that low doses also directly affects the brain energy metabolism, resulting in cognitive performance, cognitive advance, prevention of cognitive decline and improving blood flow, enhancing oxygen consumption, mitochondria and ATP production. MB has been shown in vitro studies to help all of these in humans and animals. This is especially exciting for those who have had brain traumas, stroke, or those with sleep disorder breathing patterns, but additionally it just improves oxygen and mitochondrial function so it can be utilized for general health as well.
If you’ve read some of my book (I hope you all have), you may have gotten to a section called the mighty mitochondria, where I talk about the HUGE importance of our mitochondria or energy centers in our cells being healthy. For nutrition, we ALWAYS start with mitochondrial health or energy first because if you don’t have fuel, then not only will you be tired, but also nothing will work. So many things affect our mitochondria like: infections, radiation, chemicals, heavy metals, stress, poor food choices and many many medications(some permanently damage some)…Our nerve tissue has the most mitochondria(inside the mitochondria are called electron transport chains) centers, and one of the most unique features of MB is its role in the electron transport chain and energy.
Electrons are reduced by the foods that we eat, but the food ONLY contributes to energy by producing electron donors and then donating them creating oxygen/oxidization. When the electron transport chain is coupled with adenosine it makes ATP or energy. MB inserts itself in this process because its an electron cycler, an antioxidant compound. It obtains electrons from surrounding compounds, and maintains oxygen consumption and energy production which causes oxygen to be reduced into water. Every-time that we consume oxygen, not all of the oxygen is reduced to water. The more demand we have for oxygen, the more not fully reduced oxygen called superoxide is formed. Secondly, it produces energy… It’s like a little battery. A low concentration of it reaches an equilibrium between oxidation and reduction that preserves cycling of electrons. Other compounds don’t do this.
If you have a blood flow that is impaired or you can’t get oxygenated hemoglobin to the tissues, MB can also be helpful because it optimizes the efficiency of the mitochondria respiration. So even with less oxygen available, or hemoglobin not being delivered, they’ve shown in animal studies that a loss of blood supply( you could see the beginning of memory problems and degeneration in the brain), when MB was used it prevented memory disturbances and degenerative changes.
Individuals who have chronic defects in hemoglobin( can’t get oxygenated hemoglobin to the tissues) suffer chronically with methemoglobinemia are treated life long with MB.
The blood brain barrier limits the passage of certain things into the brain, oxygen can get through, but water needs its own transport system. MB is able to pass the barrier, which has some neurologic impacts.
Other uses for MB has also been shown for : really any process where you can increase oxygen energy production you will see a benefit Dr. Lima….
Whats the proper dosage??? The uses of MB depends on its dosage. There’s something called the biphasic dose response. For practical purposes we just use mg per kg of weight.
Research shows:
The range varies from 1/2 mg per kg of body weight to about 4mg per kg of body weight.
A single dose for intervention thats acute will go up to 3-4 mg per kg body weight.
A chronic situation works for a low dose which is about 1/2-1 mg per kg of body weight.
For skin issues, combined with light (locally on the area) it is about 4mg/kg.
The research recommends to not take it every day if you are going to do low dose and to do the 1/2mg dose. If you use it everyday, the 1/2 life of orally taking it is about 12-13 hours. It primarily leaves through the urine and some of it becomes stored in the bladder. On a side note, before antibiotics were used for bladder infections, MB would be used in higher doses… Why don’t they recommend it anymore!?! Seems much more effective than ruining your gut with antibiotics, especially with the elderly who get UTIs often. It acts as a pro-oxidant killing the bacteria.
….If your urine is clear it will look more blueish, if it is more concentrated, it will look more greenish. Taking the low dose you can see how long you can urinate with discoloration, you will know theres still MB in the system, and you can wait until it’s gone to dose again.
Contraindications?? Because it is a medication, there will be contraindications. Those with the genetic variation of GSPD CANNOT take this compound as it is extremely dangerous, and those with elevated liver enzymes. Additionally, anyone taking anti depressants SSRI or SNRI cannot take this compound in high ranges. Dr. Lima stated that the problem isn’t MB its the high levels of the SSRI’s that are circulating…MB is an MAO inhibitor, which means it actually acts like an antidepressant. There’s no research that shows interactions of SSRI and MB in low doses.
Purity?? As with anything, we always want to make sure that the MB is pure. Additionally, you want to make sure it is pharmaceutical grade. There’s three types: industrial, chemical and pharmaceutical grade. Don’t go to the pet store and get MB. The industrial grade has like over half being contaminated with heavy metals… so don’t do that!
Chemical grade has a higher purity, but is still not good to give to humans. The chemical is what is used for staining purposes.
Pharmaceutical grade is what you need for highest purity and also to get the results we’re talking about here. It is mostly used through IV. However you can get an oral supply, in which you want to add in the ascorbic acid as the filler, as it facilitates the reduction of MB so it actually gets absorbed. Before MB can be entered through the cell it needs to be reduced. USP grade MB is typically recommended.
Additionally, red light has also been shown to help absorb methylene blue because the photon is the same energy as the electron. So it’s great to use with your light therapy devices! It’s shown in research to combine both for skin tumors and dermatological issues.
As with ANYTHING, it all depends on your unique biochemistry. Just because its a “good” compound doesn’t mean you necessarily NEED it.. We can get caught in that trap. So I always test it with clients and if it tests as safe, then we can incorporate it in. I’m always cautious with pharmaceuticals in the sense of I want to use more natural items to achieve results.
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That is all for now.
Wishing you all a happy and healthy week.Dr. Rachel |
Pain on the right side of your body??In the past two years with the increasing demand on our bodies detoxification systems, one organ in particular keeps taking continued hits: the liver.The Liver is our filtration organ. It’s constantly detoxing what we consume, breathe and lather on. Just like a regular filtration system, when the filter is full, it’s not very efficient. Respectively, the liver begins to sound its alarm to us that it needs a replacement, or in a more effective term HELP.Let’s first dig into the jobs of the liver:– It processes nutrients– produces bile which helps us digest fat– produces cholesterol and proteins– controls 500 metabolic processes– breakdown alcohol and medications– detoxes the blood– destroys old red blood cells– produces hormones– releases glucose into the blood– regulates and stores glycogen– stores ironThe liver is hit pretty hard when its detoxification phases get overburdened and overwhelmed. This overburdening also means that those functions I just mentioned above become difficult as the liver struggles to keep afloat because of the high load of toxins.How are toxins being administered?I think it’s an easier question to answer what isn’t being polluted.
I could go on…The point is.. our liver is SCREAMING for help. And when we don’t pay attention to the warning signs of the liver, our body will relay it in other ways called referral patterns.This brings us to the point of how the liver could be connected to the right side of the body…. There are certain pathways in our body called meridian pathways. They correlate with every organ that we have in our body. When an organ is not functioning adequately we can look to these meridians for answers as to which organ is having difficulty.The meridian of the liver is on the right side of the body, going into the right side of the head, jaw, shoulder and shoulder blade, into the right hip, knee and into the foot.This means that any of those body location areas I mentioned, could be a result of the liver screaming through that channel…. It’s not always a mechanical problem with a muscle or joint when an area is in pain/tension. In fact, most chronic pain issues are organ related.I’ve seen such a huge ramping up of the liver struggling in individuals the past two years that it’s almost not normal to find someone without a problem. Hormonal and digestive problems are another huge result of a bogged down liver, and those is through the roof!So, where does that leave us?Well, in addition to toxins that we need to take account for in our life, and begin to decrease, there’s also a couple other key points to mention with the liver.#1 there could also be an underlying infection going on in the liver making it struggle. Some big ones that I find are liver flukes (parasites), mold or mycotoxins and lyme and co-infections. The liver will always struggle when there’s unwanted guests#2 genetic hangups. Now genetics aren’t everything, we have the power to change their expression, but it is important information to know where your weaknesses might lie. For instance, there are certain genetic variations that make it difficult for a person in general to detoxify properly. Which means if they are also bombarded with more toxins they will REALLY struggle. It’s important to know these facts before going into a detox protocol and to clear things out. It could be really dangerous for a person if they don’t know these facts beforehand.What to do?Start working on what you are putting in on and around your body…. This is a big key. We can’t escape all toxins, but we can control what’s in our vicinity as best as we can.
So. If you have chronic right sided pain in your jaw, head, shoulder, hip or knee, look into your liver function. Blood lab work will often miss if the liver is starting to wane, and sometimes only reveals when it’s so far gone. But some key markers are if your liver enzymes start to rise, your cholesterol starts to rise as well as LDL, and your blood cells aren’t balanced.If you’re looking for more help with your liver, book a genetic nutrition session here:BOOK HEREAnd for those not in California, you can also book a VIRTUAL nutrition consultation through the same link.Wishing you a happy and healthy month!Dr. Rachel |