The genetic variations for ENERGY, who doesn’t need more energy?!

Happy Monday Tribe!

We are switching it up a lttle as there was no blog last week!  (Thank you for all the birthday wishes, you guys are THE BEST).

Last month we talked ALOT about the illusions of the nervous system, and ways to heal specific nerves.  If you missed any of them make sure you check out my blog online to recap, there was SOME REALLY great nuggets in there.  Especially the bit about cranial nerves!

Check it here:
https://www.drrachelhamel.com/blog-post/supercharging-your-cranial-nerves/

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This week we are shifting gears a little to talk more about genes and nutrition.  A few weeks ago I told you about the genetic mutation VDR for vitamin D and how it is SO important for the immune system, mood regulation and other. 

Before I go into more, let’s recap about genetics and nutrition for you new comers.  When looking into genes for nutrition this is what we are looking for:  enzymes.  The enzymes will either speed up or slow down a process.  Two things can happen.  You either have a homozygous gene (one from mom and dad), or heterozygous gene (one from either mom OR dad).  Each variant will inhibit the pathway its under by either 80%(homo) or 30% (hetero).  That’s a big deal!

We can’t change the genes, but we can change the way they express, and the more genetic mutations in a certain pathway, the more hindered that pathway will be.

This week I want to BRIEFLY talk about the energy pathway.  I say briefly because the energy pathways has dozens of different genes that can affect it.  I’m just going to be talking about a couple in the pathway that I see pretty commonly, and how it affects so many things, but really your ENERGY!

Who doesn’t need more energy??? Ya, I thought so.  I’m with ya there friends! 

Now, if I sent you the entire pathway of energy, your head might explode.  Ok not really, but there’s ALOT going on and a lot of you will have nightmares of your high school or college chemistry days! Or maybe some of you nerds like me will LOVE IT!

Don’t worry, I’m not going to go into it all.  I’m just going to attach a snipet here of the particular pathway we are talking about.

So the section that says #1 and #2, we are going to focus on those two areas!!
Some of you may or may not remember in those chemistry classes learning about the Krebs (or citric acid) cycle.  It’s basically the Energy Cycle.  The goal is to create something called ATP.  ATP= ENERGY, cellular energy.

ATP transports chemical energy within cells for metabolism.  It is used by enzymes and proteins in many many cellular processes that need to take place. 

Lack of ATP?

Causes issues with a build up of an amino acid called methionine and adverse response to methylated forms of supplements.  It also can result in anxiety and inflammation from high levels of glutamate.

In order to make energy which is the goal of this whole process, the ATP must be generated from something called the electron transport chain and all the processes above it.

So Let’s look at the first genetic variant NDUFS by the number 1. This gene is involved with the making of lipoic acid. Lipoic acid is needed for the electron transport chain to work and create that ATP!

This genetic mutation may be associated with: lethal neonatal disease, adult onset neurodegenerative disorders, macrocephaly with progressive leukodystrophy, encephalopathy, hypertrophic or cardiomyopathy, myopathy, liver disease, optic neuropathy, and some forms of parkinson’s disease.

Health risks:
Fatigue!!
Exercise intolerance
Weight gain
Leigh Syndrome
Neurological imbalances
Hypertrophic cardiomyopathy
Encephalopathy (maybe a reason why children get encepahology from vaccines, they can’t utilize this pathwayto clear the toxins??)
Myopathy
Liver disease
Optic neuropathy
Parkinson’s disease.

WOW right.  This is just one genetic mutation.

I should say all this info is from scientific studies on these specific genes.  We are learning more and more everyday!

So, a decrease in energy because of this ONE gene can lead up to a list of possible risks!

Let’s check out the area #2. Gene called SLC22A4, 5. 
This gene provides instructions for making a protein found in the heart, liver, muscles, kidneys and other tissue.  This protein is within the cell membrane, where it transports something called carnitine into the cell. 
Carnitine is consumed in our diet and needed to bring fatty acids into mitochondria, the energy producers in cells.  They make the ATP.

Fatty acids are a major source of energy for the heart and the muscles.  What about fasting?
During fasting, fatty acids are also an important energy source for the liver and other tissues.
With this mutation there is a shortage of carnitine within the cells.  Without this, fatty acids cannot enter mitochondria and be used to make ENERGY!

Reduced energy?
Muscle weakness and hypoglycemia.  It’s critical for elimination of many drugs and environmental toxins as well!

A buildup of this causes other symptoms:
– muscle weakness
-crohns disease
-rheumatoid arthritis
-carnitine deficiency
-fatigue
-exercise intolerance
-plaque psoriasis.

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So we’ve only gone over 2 genes.  Do you see how this can be complicated?!  Good thing is you don’t have to know it all, you just need to see someone that does!

What I am tending to find with this work is that especially for this cycle (there’s more involved here), that the chronic fatigue energy people, have a lot going on in this pathway. 

The people that always need adrenal support or energy support, coffee/tea.  
Yep, those peops. 

Instead of just giving energy supplements, you need to look at why the energy (ATP), isn’t really working!  A good portion is because of these two genetic mutations.

Through specific nutrients we can help these pathways clear up and get that energy pumping better! 

Because like I said, who doesn’t want more energy?!

Want more info!?
Schedule a genetic nutrition appointment today!
www.drrachelhamel.com or 8587755138.

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That is all for now,

Have a happy and healthy week!

 

Dr. Hamel